Combination of Serological Tests (Anti-CCP Antibody, Rheumatoid Factor IgM ELISA and Latex Test) are more Useful in Detection of Rheumatoid Arthritis

Abstract

Rheumatoid arthritis is a polyarticular and chronic inflammatory disease occurring throughout the world. To prevent significant joint damage, early diagnosis and proper treatment is of paramount importance. Though patients are diagnosed clinically supported by radiography and serological tests, early disease may present with non-specific arthritis and absence of specific radiographic findings. Though anti-CCP antibody is used for the diagnosis and may be found in early disease, recently some variability of results has been observed in some studies. In this context present study was carried out to combine anti-CCP antibody, rheumatoid factor IgM ELISA and Latex agglutination test to observe the combined specificity and sensitivity of the tests and the tests were compared with each other to examine the correlation between them.