Genotoxic Profile of Motor Garage Workers

Abstract

Problem statement: One way to study the effects on an exposed population is to conduct monitoring studies, using relevant biological parameters with a short term manifestation, such as cytogenetic analysis express the damages to the DNA or to the chromosomes resulting from exposure can be identified. The present study was thus designed to elucidate the effect motor garage environment on the workers. Approach: Peripheral blood culture was performed with blood collected from workers of Motor garages in Ahmadabad, situated at central Gujarat region. Our objective was to establish the relationship of the environment induced Micro Nucleus (MN) and Chromosomal Aberrations (CA) with non-occupational factors, such as the smoking and drinking habits since quality of life and nutritional status are the key factors that influence toxicity profile. Results: On comparing the smokers of the exposed group with that of smokers of control group the structural chromosomal aberration and micronucleus induction frequency was significant high (p<0.02) in the exposed group. Exposed individual with non smoking habit also exhibited remarkable increase in the CA and MN values with a significant increase (p<0.02) when compared with control. Considering the drinking habit of the exposed individual to that of the control, the exposed group showed significant increase (p<0.05) in the CA as well as MN. Conclusion: This indicates that occupational exposure to the many chemicals of the garage environment can have Genotoxic effects and these effects increases with the increase in period of exposure.