Effect of Triclabendazole and Levamisole on Experimental Hydatic Cyst in Rat

Abstract

Problem statement: Hydatidosis has dispersed worldly and is one of the common dangerous diseases between human and animals and is found abundantly in areas that human, dogs and herbivorous are in close relationship. Approach: In this study, firstly, 32 rats were divided into two groups of control and case and 2000 protoscolices were injected into peritoneal hole. After two months, rats of case group were feed by drinkable 5 mL Triclabendazole + 3.41 mL Levamisole for 60 days. Then after 6 months of contamination period, rats of control group and case group killed by anesthetic drug then necropsy and guts inspection of hydatid cyst was implemented. Results: The results show that in livers of control group there are 2 cysts, in kidneys 9 cysts and in lungs 87 cases. Average of contamination in this group to hydatid cyst was 32.6 but in case group there were in liver on cyst, in kidneys 5 cysts and in lungs 63 cysts. Average of guts contamination to hydatid cyst in case group was 23. Conclusion: Analyzing results in case and control groups shows that Triclabendazole + Levamisole drugs effect was 30% that this amount is not sufficient for hydatid cyst treatment.