Serum TGF-β and TNF-α During Psoriasis Therapy with Narrowband Ultraviolet B
- 1 Department of Dermatology, Faculty of Medicine, Mosul Medical College, Mosul University, Mosul, Iraq
- 2 Zhongnan Hospital of Wuhan University, Wuhan 430071, China
Abstract
Although it is now an accepted concept that narrow-band UVB therapy is an efficacious therapy for psoriasis, the relationship between the response rate and the potential effects on serum cytokines is less well-established. The purpose of this study was to investigate the correlation between the response rate and the changes of serum TGF-β and TNF-α necessary for understanding the underlying mechanisms of narrow-band UVB phototherapy. NB-UVB is effective against psoriasis without any obvious side effects and can significantly decrease serum TNF-α and promote TGF-β level of psoriasis patients. Additionally, measurement of TGF-β and TNF-αin serum could be considered as biomarkers of psoriasis activity during NB-UVB therapy.
DOI: https://doi.org/10.3844/ajassp.2014.1992.1994
Copyright: © 2014 Ahmad Taha Khalaf and Yan Yuehua. This is an open access article distributed under the terms of the
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Keywords
- Psoriasis
- Narrow-Band Ultraviolet B (NB-UVB)
- Serum Transforming Growth Factor-β (TGF-β)
- Tumour Necrosis Factor-α(TNF-α)