@article {10.3844/ajidsp.2025.15.25,
article_type = {journal},
title = {Impact of Multiplex PCR Panel on Reducing Broad-Spectrum Antibiotic Use in Ventilator-Associated Pneumonia},
author = {Staneloni, María Inés and Arriazu, Emilio F. Huaier and Burokas, Sol and Zuljevic, Nicolas and Ibañez, Guadalupe and Di Stefano, Sabrina and Venuti, Sofia and Visus, Mariángeles and Vecchio, Gisela and Sanchez, Marisa and Nemirovsky, Corina and Stanek, Vanina C},
volume = {21},
number = {2},
year = {2025},
month = {Jul},
pages = {15-25},
doi = {10.3844/ajidsp.2025.15.25},
url = {https://thescipub.com/abstract/ajidsp.2025.15.25},
abstract = {The extended use of broad-spectrum antimicrobials contribute to the growing threat of antimicrobial resistance. This study evaluated the impact of a multimodal strategy aiming at reducing the duration of broad-spectrum antimicrobial therapy in Ventilator-Associated Pneumonia (VAP). Conducted in a single Intensive Care Unit (ICU), this quasi-experimental, retrospective study compares a pre-intervention period (08/01/2018-07/01/2019) with an intervention period (08/01/2022-07/01/2023). Adult patients receiving antimicrobials for suspected VAP with positive respiratory cultures were included, 35 and 53 VAP events in the pre-intervention and intervention period, respectively. The intervention combined a diagnostic and treatment algorithm with a multiplex PCR Pneumonia Panel (PnP), education for the ICU staff, and enhanced communication with a multidisciplinary consultation group. The median time from antibiotic prescription to modification decreased from 76 h (IQR 63-100) to 21 h (IQR 8-31), a reduction of 55 h (95% CI -67, -42; p},
journal = {American Journal of Infectious Diseases},
publisher = {Science Publications}
}